Rose has been mentioned in Iranian traditional medicine as an anti-depressant, anti-anxiety with gentle aroma but powerful anti-depressant, enhancer of libido in women and men and an essential ingredient in skin care as well as stimulant effect on the human brain. Rose essential oil has been used to improve mood for a long time which results of today's studies refer to these properties. Rose essential oil aroma can help reduce anxiety and reduce the level of stress hormone to an acceptable level. In a study, the use of Rose essential oil for 8 weeks, reduced the symptoms of depression in depressed men. In another study on women who gave birth for the first time, showed that the aroma of Rose essential oil reduces anxiety. In addition, Rose Essential Oil is an effective ingredient in increasing the libido of men and women. In studies on methadone addicted men, depressed men and women, and those who use antidepressants, the use of Rose essential oil has improved sexual dysfunctions and increased levels of male sex hormone (testosterone) in men. Rose used in traditional medicine as sedative, anti-inflammatory, wound healing and laxative, especially for children and the elderly. Also, it has anti-spasm, antibacterial and antioxidant effects. Rose have been mentioned in Iranian traditional medicine as a powerful anti-depressant. Rose essential oil aroma can help reduce the level of stress hormones to an acceptable level. The effective ingredients of Rose prevent the breakdown and reabsorption of monoamines, such as serotonin and noradrenaline, which increase the amount of these neurotransmitters and thus act as an antidepressant. In a study, the use of Rose essential oil for 8 weeks, reduced depression in depressed patients. Also, studies have shown that flavonoid contained in Rose can have several effects such as sleep aid, anti-anxiety, and antidepressant effects through the gamma-aminobutyric acid pathway. Furthermore, Rose is very effective in removing inflammation and redness of the skin, removing and repairing skin ulcers, due to its richness in antioxidant and vitamin E compounds.