Bronchobarij Syrup (Anti Cough)

The Germany Commission E has approved the use of Thyme to treat cough and Bronchitis. Thymol and Carvacrol have been shown to have a wide range of effects against bacteria involved in upper respiratory tract infections. It is believed that these active ingredients add antibacterial activity by creating a complex with bacterial membrane proteins. A synergistic effect is also noted for the combination of Thymol and Creatinine. Also, the Germany Commission E has approved the use of Hollyhock for treating oral and throat mucus arthritis with dry cough. In a clinical trial, 157 patients with acute cough received this syrup (Iranian thyme and Hollyhock extract) or Dextromethorphan syrup. Based on the results, after 96 hours, 50% of patients who used this syrup were fully recovered and in the Dextromethorphan group, this number was 49.3%. Due to this product is herbal, it can be used without side effects compared to the Dextromethorphan product.

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Description

Description

Antitussive cough syrup

Cough is a disease which is usually hard to get rid of it after a viral and microbial cold. Although the treatment of this condition is longer than other common symptoms of the common cold. But if the cough has increased more than three weeks and continued for eight weeks, it should be follow up. Cough syrup which contains antitussive agents can be used as antitussive remedies.

Another type of cough is a production of phlegm that is usually followed by viral cold. This kind of cough drives the mucus from the respiratory tract. Of course, allergies or bacterial infections also develop this kind of coughs. If you are still cough weeks after a cold, see the doctor. Because coughing, which indicates the presence of a viral or bacterial agent, may lead to chronic lung disorders.

The most common symptoms of using enzyme inhibitors are Angiotensin-converting enzyme inhibitors or chronic coughing drugs. It occurs in 5-15 % of the people. This effect may be immediately followed by the beginning of the drug or subsequent months. In this case, contact your doctor immediately to give you another medication.

Chronic bronchitis is a situation in which the damage of the respiratory tract may cause cough, and sometimes with mucus. Most people with chronic bronchitis, or smoking, have a history of smoking in the past.

It should not be forgotten that some diseases are mainly associated with a long cough, diseases such as asthma, sinus infections. And also seasonal allergies, contact with smoke, and consumption of some drugs.

In typical respiratory tract infections, the cough period ranges between 10 and 14 days. And a decrease in the intensity of coughing during this period is a sign of improvement and response to treatment. In other words, the duration of treatment is usually between seven and ten days.

 

Thyme and Marshmallow, Natural Antitussive

Thyme is one of the oldest medicinal plants, such that the ancient Egyptians and ancient Greeks used Thyme to treat their diseases. The medicinal parts of Thyme are its shoots and dried leaves.

In the Middle Ages in France, Italy, and Spain, people used Thyme to treat a cough. Thyme has antibacterial properties. In some countries, such as America, people use Thyme infusion to calm the lungs and coughing during a cold.  And it still has a lot of popularity.

Marshmallow has many properties and is used in preparing herbal remedies. Marshmallow is known as vegetable medicine in many countries. Marshmallow is endemic to Europe, Africa, and Asia.

One of the most common colds is the stimulation of the nasal mucus and a severe cough. To cure these effects, there are medicinal plants that have Mucilage properties. The Marshmallow is one of the plants that are full of Mucilage, which Marshmallow very important for its effects. Mucilage is one of the interesting plants which is important in nature and way of consumption. Because of the outstanding features of this medicinal plant. It has listed in the list of World Health Organization (WHO) and Marshmallow anti-inflammatory properties have been proved.

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Indications

Adjuvant treatment for cough

Dosage form and packaging

Syrup 120 ml

Composition

* Iranian thyme (Zataria multiflora) extract
* Hollyhock (Althaea officinalis) extract

Effective Ingredients

Carvacrol, thymol, linalool, p-cymene, mucilages, amino acids and flavonoids.

Suggested Use

Take 1 full jam spoon 3 times a day.

Pharmacology

* Zataria Multiflora:
The E Commission has confirmed Thyme as a medicine for alleviating coughing and Bronchitis. A wide range of action against bacteria causing upper pulmonary infection has been reported for thymol and carvacrol. It is believed that thymol and carvacrol make complexes with proteins of the bacterial membrane . A synergistic effect has been reported for combined use of thymol and carvacrol . Carvacrol is the main component of the essential oil of Zataria Multiflora .its antibacterial and fungicidal effect has been demonstrated by tests on many micro-organisms. It has also been established that high enough doses of thymol and carvacrol have laxing effect on wind-pipe.
Essential oil of Zataria mulyiflora is effective on pathogenic bacteria such as ( S. Aureus ).It also alleviate or suppress . Symptoms such as coughing and phlegmonous reaction of upper respiratory tract .It has been used as antipasamodic and as remedy for bronchitis and spasmodic cough in adults and for whooping cough in children . Different tests have confirmed the effectiveness of Zataria Multiflora for alleviative productive cough .
In a double –blind randomized test , 60 patients suffering from phlegmonous cough were given either Zataria multiflora or Bromhexine syrup for 5 days . According to these patients’ reports on their own conditions , there has been little differences between Bromhexine and Zataria multiflora with regard to effectiveness . there was a significant difference (non- Statistically Speaking )in the speed of recovery of smokers and non-smokers of both groups ( those given Bromhexine and those Zataria multiflora).
In another double-blind randomized test on the effect of the essential oil of Zataria multiflora on coughing ,199 patients suffering from acute coughing
Were given either drops containing essential oils of sweet feneel and Zataria multiflora(3times a day 20 drops each time ),or clobutional or placebo,for 3 days .50% of those who had received zataria multiflora and sweet fennel drops and 50% of those who had received clobutional experienced total recovery .
The corresponding number for those who had received placebo was 9.1% effectiveness of zataria multiflora plus sweet fennel drops,clobutinol and placebo on those ailing from productive cough was 56.5% ,55% and 20% respectively.A statistically significant difference could be observed between zataria multiflora plus sweet fennel drops and clobutionl on one hand and placebo on the other hand (p<0.01)

* Althaee officinalis:
The E commission has confirmed by dry coughs. Althaea officinalis is also used for treatment of inflammations of respiratory tract or digestive tract , Bronchitis and coughing .Cough suppressing effect of polysaccarides separated from the essential oil of Ataea effect of the essential oil itself and that of non-narcotic based cough suppressants . According to the results, the separated polysaccharides caused a considerable reduction (Statistically) in the number of coughs and the intensity of coughing reflexes, with the effect being higher than that of the essential oil itself. Both in vitro and in vivo, rhmnogalacturonan separated from Althaea officinalis roots has shown some dosage dependent effect on coughing reflexes and reactions of smooth muscles of respiratory tract. This Substance (rhmnogalacturonan) has cough suppressant effects comparable to those attributed to codeine.However, neither in vitro nor in vivo, sensitivity of smooth muscles of respiratory tract was not greatly affected by rhmnogalacturonan . It can be stated that this substance’s cough suppressing effect is not the result of its branchodilatory effect. Moreover, its cough suppressing effect is not influenced by action of K+ATP ionic canals .it seems that rhmnogalacturonan’s cough suppressing effect is somehow related to the functioning of 5-HT2 Serotonergic receptors.

* Zataria multiflorand Althaea Officinalis:
157 patients suffering from acute coughing and aged between 10 to 85 were divided into two groups and were given either Bronchobarij Syrup ( group one -78 patients ) or dextromethorphan ( group two -79 patients )in a double –blind randomized test ; they received their respective medication of 5 m.L of either drug every eight hours for 4 days . Check lists were filled on these patients’ condition 24, 48 and 96 hours after the beginning of the medication. Recovery was expressed in three levels: total Recovery (coughing totally stopped), partial recovery (patient is satisfied that the number of coughs or their duration is reduced by half) and no recovery; intensity of coughs were recorded based on a visual Analogue Scale or VAS on each visiting of patients. Coughs were given a score of Zero (no coughing) to 10 (debilitating). According to the results of that study , 50% pf patients who had received Zataria Multiflora and Althaea Officinialis extract containing syrup corresponding number for those who had received Dexthrometorphan was 49.3% . No Statistically significant relation was perceived between the degree of recovery and the type of drug used (p= 0.94). At the beginning of the test, the average VAS score was 607 for group one and 6.8 for group two. At 24 hours ,48 hours and 96 hours from the start the average VAS score for group one were 4.4 , 3.3 and 2.67 respectively . Corresponding numbers for group two were 4.49, 3.35 and 2.4. Both drugs should statistically significant effect in all phases of the treatment (P< 0.001). Average drops in VAS score for group one at 24, 48 and 96 hours were 2.3, 3.26m3.85 respectively. Corresponding numbers for group two being 2.3, 3.4 and 4.1 with regard to suppressing cough ,no meaningful differences was perceived between the two drugs ( P> 0.006 )

Contraindications

* Pregnancy
* Breastfeeding
* Children younger than 4 years

Adverse Effects

Allergic reactions (contact dermatitis) in sensitive individuals, stimulation of mucous membrane, kidney problems in case of prolonged use or dosages higher than the recommended amount.

Interactions

Not reported

Recommendations

* Shake well before use.
* In case of allergic reactions discontinue use and consult your physician.
* Store at room temperature (15-30ºC).
* Protect from direct light and heat.
* Keep out of the reach of children.