Hyporex-B Tablet (Anti Blood Pressure)
Six groups of chemical drugs are currently used as Hypotensive drugs but cause adverse effects. Hibiscus extract has antibacterial, antioxidant, blood sugar and blood pressure lowering effect. These effects may be due to strong antioxidant activity, Alpha-glucosidase and Alpha-amylase inhibition and inhibition of Angiotensin- converting enzyme. In a clinical trial, anti-hypertensive effect of Hibiscus extract was compared with Captopril drug. Based on the results, Hibiscus managed to reduce systolic pressure from 139.05 to 123.73 mm Hg and diastolic pressure from 90.81 to 79.52 mm Hg, and there was no significant difference between two products. So Hibiscus extract can be used as anti-Hypertensive with no adverse effect that is common in chemical drugs.
Anti-Blood Pressure (blood pressure regulation)
Blood pressure refers to pressure by blood flow to the artery and is one of the vital signs. The pressure is a physical concept and the purpose of pressure refers to the “power” of a moving liquid. The blood pressure in the areas near to the heart gets more.
blood pressure regulation is the only way of controling blood pressure disease. Hypertension is basically different in different parts of the blood circulatory system. The most common way to measure blood pressure is using a barometer and the height of mercury to measure blood pressure in the vessels. However, the blood pressure is still measured in all the world with mmHg or millimeters of mercury.
High blood pressure has two categories, primary and secondary. The reason for high blood pressure is not specified in the first model. In the secondary blood pressure model, blood pressure is followed by another disease, and the disease can be considered as the cause of increased blood pressure, so if the disease controls, the blood pressure also can be controlled more appropriate.
Blood Pressure Signs
People with high blood pressure may have no signs and don’t during years and don’t know about their illness. When they notice that symptoms (such as headaches, blur and headaches, chest pain, and asthma). Therefore, the only way to get aware of this disease, is the periodic measurement of blood pressure by the Barometer.
High blood pressure or hypertension (Hypertension) is a chronic disease in which blood pressure is elevated into arteries. Following this increase in pressure, the heart must work harder to maintain blood circulation in the blood vessels more strongly than normal. Nearly 50 percent of patients do not know they have blood pressure, and also a large percentage of patients with blood pressure do not control their disease.
In some cases, the pressure of blood pressure causes a brain injury. hypertension is the major risk factor in stroke, heart attack, heart failure, arterial hypertension (e.g., aortic aneurysm). Even the slight increase in arterial blood pressure is in relation with a reduction in life expectancy. The change in diet and lifestyle can be effective in controlling blood pressure and reduce the risk of its effects on health. However, drug therapy is often necessary for people whose lifestyle changes have not been ineffective.
Hibiscus Anti-Blood Pressure properties
Hibiscus with its unique properties causes a reduction in blood pressure and blood fat as the most common diseases, and thus with using Hibiscus humans will have a longer life.
Tea has many different kinds of tea, including black tea, white tea, red tea and etc.. What makes Hibiscus more distinct is its abundance of its effects, although other teas have their own characteristics.
The acidity of this herb is known for the presence of citric acid and vitamin C. Vitamin C is one of the most important properties of this plant and also due to its properties. And a large amount of anti-fat anthocyanin and blood – hypertension and anti – cancer ingredients.
Hibiscus can cause a decrease in blood pressure in adults, according to a study conducted at the USA. It also shows this tea helps in better functioning of the heart, reduces the risk of people to cardiovascular disease.
Also, the antioxidant compounds present in Hibiscus cause blood pressure to decrease, according to researches at Tufts University. So, to observe the effect of this tea on blood pressure, three cups of Hibiscus daily for one week.
Adjuvant treatment for hypertension
Dosage form and packaging
30 Tablets – 420 mg
Hibiscus (Hibiscus sabdariffa) extract
flavonoids, hibiscus acid, various anthocyanins
Take 1 tablet with sufficient liquids 3 times a day.
Hypertension is one of the most important health challenges facing developed and developing countries and is currently a secondary death cause of cardiopathy, stroke and renal failure caused by vascular accidents. Generally, 18-54% of the global population and 29.7-34.6% of Tehranis suffer from hypertension. Pharmacological control of hypertension prevents debilitation and mortality caused by cardiovascular accidents, cerebral hemorrhage and renal failure. Currently, 6 groups of synthetic drugs are used as hypotensive agents, but they all have adverse effects. These groups include anti-adrenergics, vasodilators, Calcium antagonists, angiotensin receptor antagonists and Angiotensin Converting Enzyme Inhibitors (ACEIs). For years and in various countries, aqueous extract of hibiscus has been used to treat gastrointestinal disorders and hypercholesterolemia and as a diuretic, diaphoretic and hypotensive agent. In a study, 500 mg/kg and 1000 mg/kg doses of brewed calyces of roselle flowers significantly reduced systolic and diastolic blood pressures in hypertensive and wistar-kyoto rats (p<0.05). Pharmacological studies have shown that the hypotensive effect of hibiscus is probably induced through a diuretic and angiotensin converting enzyme inhibitory effect.
To compare the anti-hypertensive properties and tolerance of a standard extract of hibiscus with captopril, in a controlled, randomized clinical trial, 30-80 year old patients with diagnosed hypertension were asked not to use any hypotensive drug for one month prior to entering the study. They were administered for 4 weeks a tisane made with 10 g dried calyces of roselle flowers in half a liter of water (containing 9.6 mg anthocyanin) to be taken before breakfast or 25 mg captopril 2 times per day. The outcome variables included tolerance, therapeutic efficacy (a reduction in diastolic pressure of at least 10 mm Hg) and in the case of the group using hibiscus (test group), change in urine electrolytes. 90 patients entered the study. 15 patients were excluded from the study due to non-medical reasons and analysis was carried out on the data of 75 patients. Based on the results of this study, hibiscus managed to reduce systolic pressure from 139.05 to 123.73 mm Hg (p<0.03 ANOVA) and diastolic pressure from 90.81 to 79.52 mm Hg (p<0.25 ANOVA). At the end of the study, there existed no significant difference between measured blood pressure in the two treatment groups (p<0.25 ANOVA). The degree of therapeutic efficacy with hibiscus was 0.7895 and with captopril 0.8438 (p>0.560, x2) and tolerance for both groups was 100%. In the hibiscus group a natriuretic effect was observed. Gathered data showed that standardized hibiscus extract based on 9.6 mg anthocyanin and captopril (50 mg per day) do not manifest significant difference with regard to hypotensive, anti-hypertensive effects and tolerance.
To compare the therapeutic effect, tolerance, effect on serum electrolytes and ACE inhibition of a herbal medicine made from dried calyces of roselle flower with Lisinopril in patients with hypertension, a randomized, controlled, double-blind clinical trial was carried out on 25-61 year old patients of both sexes with stage I and II hypertension. The patients received for 4 weeks, 250 mg total anthocyanin in each dose or 10 mg Lisinopril. The outcome variables included therapeutic efficacy (reduction in diastolic pressure at least 10 mm Hg), safety (absence of pathologic changes in biochemical tests of liver and kidney function), tolerance (absence of serious adverse reactions), effect on serum electrolytes and effect on the activity of ACE. 193 patients entered the study [100 patients in the test group (hibiscus)], but analysis of outcome variables was carried out on 171 patients. Based on the results of this study, in the hibiscus group, blood pressure reduced from 146.48/97.77 to 129.89/85.96 mm Hg and reached an absolute reduction at 17.14/11.97 mm Hg (p<0.05, 11.58/12.21%). In the hibiscus group, therapeutic efficacy was 65.12% and tolerance and safety 100%. Reduction in blood pressure and therapeutic efficacy of hibiscus was less than Lisinopril (p<0.05). In the hibiscus group, serum chlorine increased from 91.71 to 95.13 mmol/l (p=0.0001). The level of sodium decreased (from 139.09 to 137.35, p=0.01) but potassium did not change. The activity of serum ACE was inhibited by hibiscus and decreased from 44.049 to 30.1 units (p=0.0001, us). The researchers came to the conclusion that extract of hibiscus has major anti-hypertensive effects along with considerable tolerance and safety. Also, it significantly reduces the activity of plasma ACE and decreases serum sodium without affecting potassium.
No reported contraindication
Based on the results of clinical studies carried out, use of hibiscus tea in recommended doses and even over extended periods is safe, has no adverse reaction and is well tolerated.
Concurrent use of this product with other hypotensive agents can result in more reduction in blood pressure.
* Avoid chewing Hyporex-B F.C Tablet.
* Store at room temperature (15-30ºC).
* Protect from direct light and heat.
* Keep out of the reach of children.